Xigduo XR 10/1000 mg Tablet

Q. Can I stop taking Dapagliflozin at once?
Do not stop taking Dapagliflozin at once. This can lead to a sudden increase in your blood glucose levels. Always follow the advice of your doctor for the dose and duration of your treatment. Never stop taking any medicine without consulting your doctor.

Q. Can Dapagliflozin help in the management of type 1 diabetes mellitus?
Dapagliflozin is not indicated for use in patients with type 1 diabetes mellitus. This medicine works by removing glucose through the urine and also increases the urine frequency which can worsen dehydration in these patients. There have been reports of diabetic ketoacidosis with Dapagliflozin, a complication seen in type 1 diabetic patients which may also get worsened in these patients.

Q. How is Dapagliflozin different from sitagliptin?
Both Dapagliflozin and sitagliptin are anti-diabetic drugs, but they work in different ways. Dapagliflozin is reported to be more effective in controlling blood sugar levels and also help in weight loss while sitagliptin is weight neutral. They also differ in their side effect profile as the use of sitagliptin is associated with nausea, nasopharyngitis, and pancreatitis while Dapagliflozin commonly causes urinary and genital tract infections.

Q. Can I take Dapagliflozin with metformin?
Yes, Dapagliflozin can be taken with metformin. A combined use of the two medicines can significantly improve blood glucose levels and glycosylated hemoglobin (HbA1c) and help in weight loss as compared to when either of the medicine is taken alone. No change in side effect profile has been reported compared to when they are used alone.

Q. Can I take Dapagliflozin with sulfonylureas like glimepiride?
Dapagliflozin and sulfonylureas like glimepiride, gliclazide, glyburide or glibenclamide can be taken together as it can help in better control of blood sugar levels. Use of Dapagliflozin can also help in lowering the risk of weight gain caused by sulfonylureas. However, the risk of low blood sugar levels (hypoglycemia) can increase. Consult your doctor as dose adjustment may be needed.

Q. Can the use of Dapagliflozin help in decreasing weight?
Yes, Dapagliflozin can help in lowering weight. Dapagliflozin works by removing glucose through urine, so, calories are lost resulting in weight loss according to some clinical studies. When used along with a balanced diet and exercise, it effectively lowers blood glucose levels and help in weight loss in type 2 diabetes patients.

Q. Can the use of Dapagliflozin lead to vaginal thrush (a fungal infection of the vagina)?
Yes, Dapagliflozin can lead to vaginal thrush (fungal infection of the vagina). So, it should be used with caution in patients with a history of frequent genital infections. Cleanliness of the vagina and external genitals will lower the risk of infections. Inform your doctor if you have painful urination, redness, itching or swelling of your genitals while taking this medicine.

Q. How is Dapagliflozin different from liraglutide?
Both are anti-diabetic medicines and lower blood glucose levels effectively and also help to lower weight. However, they differ in many ways. Dapagliflozin is to be taken by mouth and it lowers blood glucose levels by removing glucose from the body through urine and can cause urinary and genital tract infection. While liraglutide is an injectable which lowers blood glucose levels by the release of insulin and its use is commonly associated with nausea and there have been rare reports of pancreatitis in patients using this medicine.

Q. How long can Dapagliflozin take to show improvement of my conditions?
Dapagliflozin starts to show its effect from the first dose itself, however, it shows its maximum effect after 1 week of starting the medicine.

Q. Is Dapagliflozin better than canagliflozin?
Both Dapagliflozin and canagliflozin belong to the same class of drugs and work by removing glucose from urine. However, some clinical studies reported that canagliflozin is more effective in removing a higher amount of glucose through urine in 24 hours than Dapagliflozin. Also, the use of Dapagliflozin is advised to be avoided in patients with bladder cancer.

Q. Is Dapagliflozin better than gliclazide?
Both Dapagliflozin and gliclazide are anti-diabetic drugs however, they work in different ways and have different side effect profile. Gliclazide commonly causes low blood sugar levels while the use of Dapagliflozin is associated with urinary tract and genital infections. Dapagliflozin causes low blood sugar levels mostly when taken with insulins or sulfonylureas and it helps in weight loss compared to gliclazide which causes weight gain.

Q. Is Dapagliflozin better than metformin?
Both Dapagliflozin and metformin are effective in lowering blood glucose levels, however, they work in different ways and have different side effect profile. Metformin restores the body's ability to use insulin, lowering the blood sugar levels whereas Dapagliflozin works by increasing the amount of glucose that gets passed out in the urine. Metformin commonly causes nausea, vomiting, altered taste, abdominal pain, loss of appetite while Dapagliflozin is associated with nausea, increased thirst, urinary and genital tract infections.

Q. Is Dapagliflozin effective?
Yes, Dapagliflozin is effective if used for the right indication in the dose and for the duration as advised by the doctor. In case you do not find any change in your disease condition while taking this medicine, please talk to your doctor. Do not change the dose or stop taking the medicine without consulting your doctor.

Q. Can Dapagliflozin be taken along with canagliflozin?
No, it is not advisable to take Dapagliflozin with canagliflozin. Both belong to the same class of anti-diabetic drugs and work in the same way. Together they may be more efficacious but there could also be an increased risk of side effects caused by them.

Q. Can the use of Dapagliflozin cause urinary tract infections?
Yes, urinary tract infections is a reported side effect of Dapagliflozin. So if you observe pain or burning sensation while urinating consult your doctor. Drinking plenty of fluids as this may reduce burning sensation.

Q. What effect does Dapagliflozin have on renal impairment?
Dapagliflozin is not recommended for use in patients with moderate to severe renal impairment with eGFR (estimated glomerular filtration rate) less than 60 mL/min/1.73m2. It may cause an increase in creatinine, phosphorus and parathyroid hormone (PTH) levels and can cause fall in blood pressure hypotension. So inform your doctor if you have an underlying kidney disease before taking this medicine.

Q. What is the effect of the Dapagliflozin on cancer?
There is no such effect reported on cancer but some studies have shown an increased risk of bladder cancer with Dapagliflozin so use is avoided in patients with a history of bladder cancer and along with drugs like pioglitazone.

Q. What are the contraindications to use of Dapagliflozin?
Use of Dapagliflozin is not recommended in patients with a history of serious hypersensitivity reaction to Dapagliflozin, severe kidney disease, end-stage kidney disease, or dialysis.

Q. Does Dapagliflozin worsen euglycemic diabetic ketoacidosis?
Dapagliflozin may worsen diabetic ketoacidosis (increased total body ketone concentration, metabolic acidosis, and very high blood sugar levels). Dapagliflozin is not advised to be taken in this condition. The patient may experience nausea, vomiting, anorexia, abdominal pain, excessive thirst, difficulty breathing, confusion, unusual fatigue or sleepiness. Inform your doctor if you have these signs-symptoms while taking this medicine.

Q. Is Metformin helpful in patients with polycystic ovarian syndrome (PCOS)?
Metformin is safe and helpful for the patients who have PCOS as it can cause ovulation and can regularize the menstrual cycles when combined along with other medications. It also helps in maintaining the diet and prevents the development of diabetes..

Q. How does Metformin help in weight loss?
Though it is not yet recommended for reduction in weight, it can be effectively used since it reduces the hunger thereby decreasing food intake. Metformin present in the body creates insulin thereby reducing the glucose production in conjunction with a decrease in fat deposits that helps to reduce the body weight..

Q. Is Metformin useful in the treatment of infertility?
Metformin can be used for infertility treatment in conjunction with PCOS by regulating the level of ovulation and androgen and by improving the menstrual cycle regularity and rates of pregnancy. This effect is considered due to the insulin resistance of Metformin.

Q. Does Metformin cause low blood sugar levels (hypoglycemia)?
Intake of Metformin can cause hypoglycemia(low blood sugar level).It happens if you take any other antidiabetic medicine along with Metformin, miss your food, drink alcohol or do more exercise.So, be cautious about the symptoms of low blood sugar and always carry glucose, honey, or fruit juice along with you.

Q. Can I take Metformin forever?
Metformin is safe to use if so it is used at prescribed doses for the prescribed duration as per the advice of the doctor since overuse of drug may cause anaemia and nerve damage called peripheral neuropathy..

Q. Is Metformin a sulfonylurea?
Metformin is an anti-diabetic drug which is used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with the modification in diet and exercise.It is not a sulfonylurea

Q. Is Metformin a steroid?
Metformin is an anti-diabetic drug which is used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with the modification in diet and exercise.It is not a steroid

Q. Does Metformin cause bloating?
Metformin normally causes stomach upset like bloating (heavy and uncomfortable feeling within the stomach), nausea, vomiting, and diarrhea.It is advised to be taken after food and start with low dose initialy and increase it slowly..

Q. Is Metformin good for fatty liver?
Metformin can be beneficial in the treatment of non-alcoholic fatty liver disease (NAFLD). Insulin resistance is one of the underlying cause of NAFLD.Metformin improves insulin resistance and liver enzymes in these patients It is not beneficial to patients with alcoholic fatty liver disease and is usually avoided in patients with liver cirrhosis as they are at an increased risk of lactic acidosis.

Q. What is the benefit of combining Metformin with coenzyme q10?
Coenzyme Q10 is found in heart, liver, kidney, and pancreas (which produces insulin) it is an antioxidant that helps in energy production. It can repair the damage caused to these organs by free radicals.It is seen that the levels of coQ10 is low in diabetics hence it has to be given from outside.Metformin and CoQ10 can be taken together as no drug drug interactions are caused by the two.

Q. Does Metformin help in improving your menstrual cycle (periods)?
In women with the polycystic ovarian syndrome (PCOS) Metformin improves the menstrual cycle (periods) regularity. It is associated with decreased ovulation, high androgen levels, and insulin resistance which cause menstrual irregularities like scanty bleeding and delayed periods .Metformin helps in improving insulin sensitivity, ovulation rate, and decreasing androgen levels hence, regularizing menstrual cycles.

Q. Can I take Metformin with atorvastatin?
Yes, Metformin and atorvastatin can be taken together. There are no reported harmful effects while they are used together. Some research says that it is beneficial in diabetics as they may prevent a very high increase in blood glucose after a meal, decrease some inflammation markers and secure the patients from liver injury.

Q. Can I take Metformin with phentermine?
Metformin and phentermine can be taken together. These are given together in obese patients who are also diabetic and are taking Metformin along with exercise and diet modification. Phentermine decreases food intake by its action in the brain. However, a dose adjustment of Metformin may be needed as phentermine can decrease the effect of Metformin leading to very high blood glucose levels.

Q. Can I take Metformin with levothyroxine?
Metformin and levothyroxine can be taken together but a dose adjustment of Metformin is needed . Levothyroxine can decrease the effect of Metformin leading to very high blood glucose levels. In patients with coexisting thyroid disease and diabetes mellitus or polycystic ovarian syndrome (PCOS) these are used together.

Q. Can I take Metformin with prednisolone?
Metformin and prednisolone can be taken together but a dose adjustment of Metformin is needed. The effect of Metformin can be decreased by Prednisolone leading to very high blood glucose levels. Regular use of steroids like prednisolone can also cause diabetes known as glucocorticoid-induced diabetes and use of Metformin is recommended in these patients..

Q. Can I take Metformin with metoprolol?
Yes, Metformin and metoprolol can be taken together. There are no reported harmful effects while they are used together.However, some animal studies suggest that metoprolol can decrease the blood levels of Metformin and on long-term use can increase lactic acid and uric acid levels.

Q. Does Metformin clear acne?
Metformin only helps in clearing acne in women with polycystic ovarian syndrome (PCOS) along with other problems like facial hair, abdominal obesity, and irregular menstruation.Metformin is not indicated for clearing acne due to other conditions.

Q. Does Metformin cause hair loss?
No, hair loss has not been reported with Metformin. It only helps in clearing facial hair (hirsutism) in women with polycystic ovarian syndrome (PCOS) along with other problems like acne, abdominal obesity, and irregular menstruation.

Q. Does Metformin cause weight gain?
Metformin helps in decreasing weight especially abdominal fat patients of type 2 diabetes mellitus and in women with polycystic ovarian syndrome (PCOS) along with other problems like facial hair, acne, and irregular menstruation.Metformin does not cause weight gain.

Q. Does Metformin cause constipation?
use of Metformin may cause nausea, vomiting, abdominal pain, altered taste, diarrhea, and loss of appetite. Metformin does not cause constipation..

Q. Is Metformin safe?
Metformin is safe to use if so it is used at prescribed doses for the prescribed duration as per the advice of the doctor. However use of Metformin may cause nausea, vomiting, abdominal pain, altered taste, diarrhea, and loss of appetite.

Q. Does Metformin increase blood pressure?
useof Metformin may cause nausea, vomiting, abdominal pain, altered taste, diarrhea, and loss of appetite.Metformin does not increase blood pressure.

Q. Is Metformin an insulin?
Insulin is a normally produced hormone in the body, used in the injectable form in the treatment of both type 1 and 2 diabetes mellitus and it works by absorbing and storing glucose from the blood.Metformin is not an insulin, it is oral drug used in type 2 diabetes mellitus and lowers blood glucose levels by decreasing its production and increasing absorption and making the already available insulin in your body to work better

Q. Is Metformin a banned drug?
Metformin is not a banned drug. It is a prescription medicine available only on prescription.

Q. Is Metformin a birth control pill?
Metformin is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients , along with modification in diet and exercise.It is not a birth control pill.

Q. Is Metformin a statin?
Metformin is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients , along with modification in diet and exercise.It is not a statin.

Q. Can I take Metformin with saxagliptin?
Metformin and saxagliptin belong to the same class of drugs called anti-diabetics but work with different mechanism of action.A fixed dose combination is available in the market and is generally prescribed when Metformin is unable to control blood sugar levels even after giving the maximum tolerated dose.

Q. Does Metformin cause blurry vision?
Change in vision in a patient with diabetes could be due to varous reasons. It could be a temporary problem either due to high blood sugar levels which cause your lens inside your eye to swell and change your vision. If the blurred vision continues for a long time, consult a doctor.As Metformin is not known to cause blurred vision.

Q. What is lactic acidosis and how is it related to Metformin use?
Patient has high blood lactic acid levels and may present with tiredness, weakness, stomach pain, loose stools, severe muscle pain, muscle cramps and difficulty in breathing. It is especially seen in old age patients, those with kidney, liver or heart disease, or who take large amounts of alcohol. If you have these symptoms, stop taking Metformin and consult your doctor. Lactic acidosis is a rare, but serious complication associated with the use of Metformin.

Q. Is Metformin use associated with liver pain?
Metformin is not known to cause any liver pain or damage. Rather, it is seen to be useful in patients with non-alcoholic fatty liver disease (NAFLD) and chronic hepatitis C. However, it is usually avoided in patients with liver cirrhosis as they are at an increased risk of lactic acidosis which is a serious complication associated with the use of Metformin.

Q. Does Metformin make you feel high?
Metformin is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modification in diet and exercise. Metformin does not make you feel high. Rare side effects of Metformin include anxiety and depression.

Q. Can Metformin cause back pain?
Metformin generally does not cause back pain. Metformin may cause side effects like stomach upset, bloating (heavy and uncomfortable feeling in the stomach), nausea, vomiting, and diarrhea, or it could be a symptom of lactic acidosis, a rare and a serious complication of Metformin.

Q. Can long-term use of Metformin cause vitamin b12 deficiency?
Yes, long term use of Metformin causes vitamin B12 deficiency as it interferes with absorption of vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems and the patient can have tingling sensation and numbness in hands and feet, weakness, urinary problems, change in mental status and difficulty in making balance (ataxia). To avoid these problems, some researchers suggest an intake of vitamin B12 from outside at least once every year.

Q. Is Metformin useful in the management of metabolic syndrome?
Metformin is an insulin sensitizer and it improves the action of insulin and normalises blood sugar levels and reduces body weight. Metformin is beneficial in the management of metabolic syndrome, a collection of risk factors that include high blood pressure, high blood sugar levels, abnormal blood cholesterol levels and excess fat around the waist.

Q. How beneficial is it to take Metformin with glimepiride?
Metformin and glimepiride belong to the same class of drugs called anti-diabetics but work with different mechanism of action and helps in better control of blood glucose levels when taken together.However, glimepiride can cause very low blood glucose levels, so a regular monitoring of blood glucose is very important.

Q. Is it safe to take Metformin with cetirizine?
Yes, Metformin and cetirizine can be taken together. There are no reported drug interactions or serious effects when they are taken together.

Q. Can I take Metformin and ranitidine together?
Metformin and ranitidine can be taken together. However, if you are taking them together, you need to monitor blood glucose levels regularly as ranitidine can decrease the removal of Metformin from the body and increase its blood levels. This can cause very low blood sugar levels and other side effects as well hence, a dose adjustment of Metformin may be needed.

Q. How beneficial is it to take Metformin with linagliptin?
Metformin and linagliptin belong to the same class of drugs called anti-diabetics but work with different mechanism of action.A fixed dose combination is available in the market and is generally prescribed when Metformin is unable to control blood sugar levels even after giving the maximum tolerated dose.

Q. Does Metformin inhibit hepatitis B virus protein?
Studies have shown that Metformin when given with other antiviral drugs can decrease the multiplication and growth of hepatitis B virus .However, this is indication is still under research and not yet approved.

Q. Can I take Metformin before or after a chest x-ray? Does its use lead to chest x-ray abnormality?
Metformin should be temporarily discontinued before chest or any X-ray that requires injection of a contrast medium or dye. These dyes can decrease kidney function and Metformin along with these dyes can cause a serious side effect like lactic acidosis. So you may need to stop taking Metformin. However, do not stop taking any medicine without talking to your doctor.

Q. Does Metformin make you sleepy?
Yes, Metformin causes sleepiness it is an early symptom of lactic acidosis along with tiredness, weakness, stomach pain, loose stools, severe muscle pain, muscle cramps and difficulty in breathing. It is caused by Metformin and usually seen in old age patients, those with kidney, liver or heart disease, or those who take large amounts of alcohol. If you have these symptoms, stop taking Metformin and consult your doctor.

Q. Does the use of Metformin cause joint pain?
Metformin does not cause joint pain. Use of anti-diabetic drugs like sitagliptin or saxagliptin is associated with joint pain. Early symptoms of lactic acidosis like muscle pain and cramps with weakness and tiredness can be mistaken for joint pain.However, diabetes itself decreases blood circulation to the joints and even damages them leading to joint pain.

Q. Can Metformin help in reducing weight gain caused by antipsychotics?
Metformin improves insulin sensitivity and prevents weight gain, use of antipsychotics affects both these factors. Metformin may be beneficial in the treatment and prevention of weight gain caused by antipsychotics along with lifestyle modifications like a change in diet and regular exercise. Weight gain is an important reason for discontinuation of these medicines.

Q. Is Metformin useful in the treatment of fragile X syndrome?
Metformin is still not approved for the treatment of fragile X syndrome. However, in some animal research studies it has shown promising resultsin the treatment of fragile X syndrome. It may be beneficial in improving mental and behavioral disorders (autism) and control obesity and risk of developing diabetes in these patients.

Q. What is the difference between liraglutide and Metformin?
Metformin and liraglutide belong to the same class of drugs called antidiabetic drugs and both control blood sugar levels effectively. liraglutide is an injectable and it increases insulin release from the pancreas.whereas, Metformin is taken by oral route and it decreases glucose production from liver and glucose absorption from the gut and increases insulin sensitivity. liraglutide increases the risk of pancreatitis. Metformin and liraglutide both cause stomach upset, like nausea, vomiting, diarrhea and bloating.

Q. Does Metformin use make you feel high?
Metformin is an antidiabetic drug used to control high blood sugar levels in newly-diagnosed type 2 diabetes patients, along with modification in diet and exercise. Metformin does not make you feel high. Rare side effects of Metformin include anxiety and depression.

Q. Does Metformin make you sweat?
sweating is one of the side effects of Metformin.However, the exact cause of this is not known. Some researchers suggest it to be due to low blood sugar levels especially at night which can cause night sweats as well. Monitor your blood sugar levels regularly and talk to your physician as a dose adjustment may be needed.

Q. Can I take Metformin with clomiphene citrate?
Metformin and clomiphene citrate can be taken together. In patients with polycystic ovarian syndrome (PCOS) and infertility they are advised together. some studies have shown an improvement in ovulation and pregnancy rates in these patients as compared to use of clomiphene citrate alone or if the patients are resistant to the effects of clomiphene citrate. However, this is still under research.

Q. Is Metformin useful in treating or preventing breast cancer?
As high insulin levels are known to increase the risk of cancer, Metformin decreases cancer cell growth by decreasing insulin and blood glucose levels. Research say Metformin is seen to be beneficial in the treatment and prevention of cancers especially breast cancer. However, its use in treating breast cancer is not yet approved.

Q. Does Metformin use increase your chance to get Helicobacter pylori infection?
Diabetes itself increases the risk of Helicobacter pylori infection which increases the chances of stomach upset like nausea, vomiting, diarrhea, and bloating by Metformin. Metformin is not associated with an increased risk of Helicobacter pylori infection.

Q. Does Metformin use leads to anemia?
Long term use of Metformin decreases levels of vitamin B12 which may cause anemia (megaloblastic anemia) in which blood cells are larger than normal. You need to include foods rich in vitamin B12 in your diet like eggs, dairy products, meat or supplements from outside.

Q. Is Metformin useful in the treatment of prediabetes?
Metformin makes insulin already available in your body to work more effectively, it decreases glucose production by liver and increases use of glucose by the muscles and lowers body weight Metformin is seen to be useful in the management of prediabetes, a condition with blood glucose levels higher than normal but not high enough to label you as diabetic. However, lifestyle modifications like a change in diet and exercise should be tried first as they are seen to be more effective than Metformin.

Q. Can I take Metformin with teneligliptin?
Metformin and teneligliptin can be taken together. Even after taking Metformin if the blood sugars are very high it is a good add-on treatment. The risk of low blood sugar levels (hypoglycemia) is also very low with both the medicines. However, consult your doctor before taking them together as a dose adjustment may be needed.

• Dapagliflozin is used alone or together with other diabetes medicines to control blood sugar and avoids long-term complications. It also reduces the risk of heart attack, heart failure or other cardiovascular events.You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines (if prescribed) along with Dapagliflozin.Dapagliflozin may also reduce weight and blood pressure.It may cause your body to lose too much fluid (dehydration) or you to urinate more often. Drink plenty of water and stay hydrated. It can cause genital fungal and/or urinary tract infections (UTIs) in both females and males, so practice good hygiene.It can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal. Monitor your blood sugar regularly.Always carry some sugary food or fruit juice with you in case you experience hypoglycemia symptoms such as cold sweats, cool pale skin, tremor, and anxious feeling.Inform your doctor immediately if you experience constant dizziness, joint pain, cold-like symptoms, or unexplained nausea/vomiting.
• You have been prescribed Metformin to control the blood sugar level and reduce the risk of diabetic complications, such as heart  attacks.You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines (if prescribed) along with Metformin.It does not cause weight gain and rarely causes low blood sugar unlike other diabetes medicines.An upset stomach with nausea and diarrhoea may occur in the first two weeks; take it with food to avoid an upset stomach.Hypoglycemia (low blood sugar level) may occur when taken along with other antidiabetic medicines, alcohol or on delaying/skipping a meal. Carry a sugar source with you for immediate relief.Tell your doctor immediately if you experience any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain as Metformin may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.Vitamin B12 deficiency and symptoms of anemia like fatigue, pale skin, shortness of breath or headache may occur. Notify your doctor if you experience any of these as you may require supplements.Your doctor will monitor your blood sugar levels and kidney functions regularly while taking this medication.