Pregabid D 75 mg Tablet

Q. Is Duloxetine a non-steroidal anti-inflammatory drug (NSAID)?
No. Duloxetine is not a non-steroidal anti-inflammatory drug (NSAID). It belongs to the anti-depressant class of drugs, more specifically SNRI (Serotonin-Norepinephrine Reuptake Inhibitor). It works by increasing the levels of chemical messengers (serotonin and noradrenaline) in the nervous system.

Q. Is Duloxetine a steroid?
No. Duloxetine is not a steroid. It belongs to the anti-depressant class of drugs, more specifically SNRI (Serotonin-Norepinephrine Reuptake Inhibitor). It works by increasing the levels of chemical messengers (serotonin and noradrenaline) in the nervous system.

Q. Is Duloxetine a blood thinner?
No. Duloxetine is not a blood thinner. Blood thinners prevent the formation of harmful blood clots.

Q. Is Duloxetine a stimulant?
No. Duloxetine is not a stimulant. Stimulants are the medicines which activate the central nervous system.

Q. Is Duloxetine a pain killer?
No. Duloxetine is not a classical painkiller e.g. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs).Duloxetine is used for the treatment of chronic pain conditions like neuropathic pain, diabetic neuropathy or fibromyalgia.

Q. Is Duloxetine a tricyclic antidepressant (TCA)?
No. Duloxetine is not a tricyclic antidepressant (TCA). It belongs to a class of anti-depressants called SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors).

Q. Is Duloxetine a benzodiazepine?
No. Duloxetine is not a benzodiazepine. It belongs to a class of anti-depressants called SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors). Benzodiazepines belong to the sedative-hypnotic class of drugs and include agents like diazepam, lorazepam, alprazolam etc.

Q. Is Duloxetine a narcotic?
No. Duloxetine is not a narcotic. It means it does not have habit-forming potential. Narcotics are the substance which can cause addiction and dependence.

Q. Is Duloxetine a psychotropic?
Yes. A psychotropic is a medicine that affects mind, emotions, and behaviour. Duloxetine, being an anti-depressant agent reduces the symptoms of depression and is a psychotropic agent.

Q. Can I take Duloxetine if I have Hepatitis C virus infection?
Duloxetine should be used with caution in patients with Hepatitis C virus infection. Cases of liver injury, including severe elevations of liver enzymes (>10-times upper limit of normal), hepatitis, and jaundice have been reported with Duloxetine. Taking Duloxetine increases the risk of liver toxicity and fatty liver in Hepatitis C virus-infected patients.<br>

Q. What is the peak plasma concentration [Cmax] of Duloxetine?
The maximum plasma concentration [Cmax] of Duloxetine is 6 hours post oral dose. Food taken with Duloxetine may delay the time to reach the peak plasma concentration from 6 to 10 hours. This may marginally decrease the extent of absorption (approximately 11%).

Q. Can I take Duloxetine with Vitamin D?
Yes. Duloxetinecan be taken with vitamin D. It does not have any known interaction with Vitamin D.

Q. What is half life of Duloxetine?
The elimination half-life of Duloxetine ranges from 8 to 17 hours (mean 12 hours).

Q. Which is better in depression, Duloxetine or fluoxetine?
Fluoxetine has not been found to be different in either tolerability or efficacy when compared with Duloxetine in major depression. Duloxetine is good for treating depression, anxiety and may help with chronic pain.

Q. Which is better Duloxetine vs sertraline?
Duloxetine and sertraline are found to be equally effective in the treatment of Major Depressive Disorder (MDD). Certain symptoms like agitation and anxiety are reduced better by sertraline. Duloxetine has been found to be better than sertraline for neuropathic pain.

Q. Which is better for chronic pain, Duloxetine or pregabalin?
In patients with fibromyalgia Duloxetine is found to be better than pregabalin in reducing depressed mood. Pregabalin is better in reducing fatigue. Duloxetine and pregabalin generally provide equally comparable pain relieving efficacy in the treatment of diabetic peripheral neuropathic pain (DPNP).

Q. Which is better Duloxetine or fluoxetine?
Duloxetine has been found to be better for the treatment of chronic pain than Fluoxetine. Fluoxetine is good for treating depression and anxiety.

Q. Which is better for depression, Duloxetine or mirtazapine?
Currently, there is not enough information to firmly recommend one antidepressant over another. However, both these drugs have been found to be safe and efficacious in the treatment of depression.

Q. Which is better for depression, Duloxetine or venlafaxine?
Currently, there is not enough information to firmly recommend one antidepressant over another. Many doctors favour Duloxetine over venlafaxine when pain conditions coexist with depression.

Q. Is Duloxetine a barbiturate?
No. Duloxetine is not a barbiturate. Barbiturates belong to the Sedative-Hypnotic class of drugs and are likely to have abuse potential.

Q. When to take Duloxetine?
Duloxetine can cause difficulty in sleep (insomnia). Hence, it is advised to be taken in the morning than at night.

Q. When does Duloxetine start working?
Usually, the action of Duloxetine takes about three to four weeks to appear. Do not discontinue the therapy in between, thinking that it is not effective.

Q. How much dose of Duloxetine can produce overdose?
Overdose can occur at a doses as low as 1000 mg. Signs and symptoms of overdose (Duloxetine alone or in combination with other medicinal products) included somnolence, coma, serotonin syndrome, seizures, vomiting and tachycardia.

Q. How does Duloxetine work in urinary incontinence?
Duloxetine is thought to work by interfering with certain chemicals (called serotonin and noradrenaline) that are used within the nerves that send messages to your pelvic floor muscles. This helps the muscles around the bladder outlet to contract more strongly, and this in turn controls the flow of urine and helps to prevent any leakage.

Q. Can I take Duloxetine with amitriptyline?
It is better to avoid Duloxetine and amitriptyline together. It can increase the risk of a serious condition called the serotonin syndrome, with symptoms such as confusion, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea.

Q. Can I take Duloxetine with sertraline?
It is better to avoid Duloxetine and sertraline together. It can increase the risk of a serious condition called the serotonin syndrome, with symptoms such as confusion, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea.

Q. Can I take Duloxetine with tramadol?
Duloxetine and tramadol together can increase the risk of a serious condition called the serotonin syndrome, with symptoms such as confusion, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Please inform your doctor if you are taking any of these medicines before coming to him.

Q. Can I take Duloxetine with bupropion?
Bupropion can cause inhibition of metabolism of Duloxetine in the body, resulting in toxic effects of Duloxetine. The concomitant use of these two drugs can result in seizures. Mention it to your doctor if you are taking any of these medications from before.

Q. Which is better in diabetic neuropathy, Duloxetine or pregabalin?
In patients with fibromyalgia, Duloxetine is found to be better than pregabalin in reducing depressed mood. Pregabalin is better in reducing fatigue. Duloxetine and pregabalin generally provide equally comparable pain relieving efficacy in the treatment of diabetic peripheral neuropathic pain (DPNP).

Q. Can Duloxetine get me high?
No. Duloxetine does not cause a high. It does not create a feeling of euphoria and has no recreational potential.

Q. Can I use Duloxetine for arthritis?
Duloxetine is not approved for the treatment of arthritis. It is used in the treatment of depression, anxiety disorder, diabetic nerve disease, neuropathic pain and overactive urinary bladder.

Q. Can I use Duloxetine for sciatica?
No, Duloxetine is not approved for the treatment of sciatica. It is used in the treatment of depression, anxiety disorder, diabetic nerve disease, neuropathic pain and overactive urinary bladder.

Q. Can I use Duloxetine for obsessive-compulsive disorder (OCD)?
Obsessive-compulsive disorder (OCD) is a type anxiety disorder. It is approved for the treatment of obsessive-compulsive disorder. Research studies suggest that Duloxetine may provide a significant reduction in symptoms for patients with obsessive-compulsive disorder.

Q. Can I use Duloxetine for hot flashes?
No. Duloxetine is not approved for use in hot flashes. It may be used in the treatment of depression in postmenopausal women suffering from menopausal vasomotor symptoms (hot flashes, night sweats) and insomnia.

Q. Can I use Duloxetine for headaches?
No, Duloxetine is not approved for use in headaches. It is used in the treatment of depression, anxiety disorder, diabetic nerve disease, neuropathic pain and overactive urinary bladder.

Q. Can I use Duloxetine for a migraine?
No. Duloxetine is not approved for use in a migraine. It is used in the treatment of depression, anxiety disorder, diabetic nerve disease, neuropathic pain and overactive urinary bladder.

Q. Can I use Duloxetine for chronic pain?
Duloxetine is approved for the treatment of chronic pain states including neuropathic pain (nerve pain) associated with Diabetes Mellitus and fibromyalgia.

Q. Can I use Duloxetine for nerve pain?
Yes. Duloxetine is approved for use in nerve pain or neuropathic pain conditions, most commonly seen in patients suffering from Diabetes Mellitus.

Q. Can Duloxetine raise blood sugar levels?
No. Duloxetine may affect blood sugar levels. If you are diabetic and notice a change in the results of your blood or urine sugar tests, check with your doctor.

Q. Is Pregabalin a metabolite of gabapentin?
No. Pregabalin a not a metabolite of gabapentin. There is a structural similarity between the two drugs and they are GABA analogue.

Q. Can Pregabalin cause sedation?
Yes, use of Pregabalin can cause sedation or sleepiness.

Q. Is Pregabalin a beta blocker?
No. Pregabalin is not a beta blocker. Pregabalin is a medicine which is used for conditions like neuropathic pain, anxiety, epilepsy, and fibromyalgia.

Q. Is Pregabalin a mood stabiliser?
No. Pregabalin is not a mood stabiliser. Pregabalin is a medicine which is used for conditions like neuropathic pain, anxiety, epilepsy, and fibromyalgia.

Q. Is Pregabalin a muscle relaxant?
No. Pregabalin is not a muscle relaxant. Pregabalin is a medicine which is used for conditions like neuropathic pain, anxiety, epilepsy, and fibromyalgia.

Q. Is Pregabalin a benzodiazepine?
No. Pregabalin is not a benzodiazepine. Pregabalin is a medicine which is used for conditions like neuropathic pain, anxiety, epilepsy, and fibromyalgia.

Q. Is Pregabalin a painkiller?
No. Pregabalin is not a pain killer. Pregabalin is used in the treatment of neuropathic pain, epilepsy and anxiety disorder.

Q. Is Pregabalin a steroid?
No. Pregabalin is not a steriod. Pregabalin is a medicine which is used for conditions like neuropathic pain, anxiety, epilepsy, and fibromyalgia.

Q. Is Pregabalin a narcotic?
Pregabalin is definitely not a narcotic drug. Narcotics are usually derivatives of Opium like Morphine & Heroin and they have sleep-inducing properties. Pregabalin is a medicine which is used for conditions like neuropathic pain, anxiety, epilepsy, and fibromyalgia.

Q. Is it safe to take Pregabalin with duloxetine?
If Pregabalin and duloxetine taken together, there is an increased risk of side effects like dizziness, drowsiness, confusion, and difficulty in concentrating and motor co-ordination. Consult with your doctor if you have already taken one of the medications.

Q. What is the interaction of Pregabalin with anticoagulants?
There is no known interaction between the two drugs but consult your doctor and inform if you are taking any of the medication.

Q. Is Pregabalin safe?
Pregabalin is a prescription drug and is safe to use if taken in the dose, frequency, and duration as per the doctor's advice.

Q. Are Pregabalin and gabapentin the same?
Pregabalin and gabapentin are two different medicines. However, they work in a similar way and both are used for conditions like neuropathic pain and epilepsy. Pregabalin is also used for treating anxiety. Please consult your doctor before using any of the medicine.

Q. Is Pregabalin a non-steroidal anti-inflammatory drug (NSAID)?
No, Pregabalin is not a non-steroidal anti-inflammatory drug (NSAID). IIt is a medicine which decreases pain and seizures or fits by binding to specific calcium channels and increasing the action of GABA, a chemical messenger in the nerve cells and is used for conditions like neuropathic pain, anxiety, epilepsy, and fibromyalgia.

Q. Can I take Pregabalin with methadone?
Methadone is opioid in nature and It may reduce the lower gastrointestinal tract function (e.g., intestinal obstruction, paralytic ileus, constipation) especially when given with Pregabalin. So, when Pregabalin and opioids are used together, measures to prevent constipation may be considered (especially in female patients and elderly).

Q. Is Pregabalin a controlled substance?
No, Pregabalin is not a controlled substance. However, it is a prescription drug which should only be taken as per the doctor's advice.

Q. How long can I take Pregabalin for?
Pregabalin is a prescription drug and it should only be taken for the duration as advised by the doctor.

Q. Can I take Pregabalin with gabapentin?
Pregabalin and gabapentin both act via similar mechanism and are used for treating similar conditions. They may also enhance each other's depressant action, so, taking both together is not recommended as you may feel more sleepy and need to take more precautions while driving or using machines. Please consult your doctor before taking both the medicines together.

Q. Can I take Pregabalin with sertraline?
Pregabalin may increase the depressant action of sertraline. Taking them together can make you feel more sleepy, so, you should be careful while driving or if you are working with a machine. Consult your doctor before taking these drugs together.

Q. Can I take Pregabalin with naproxen?
Pregabalin and naproxen are not known to have any clinically relevant interaction. However, interactions may occur. Please consult your doctor before taking both them together.

Q. Can I take Pregabalin with tramadol?
The central nervous system depressant effect of tramadol may increase when it is taken with Pregabalin and you can feel more sleepy, so, you should be careful while driving or if you are working with a machine. Consult your doctor before taking both the medications together.

Q. Can I take Pregabalin with alprazolam?
Pregabalin can be taken with alprazolam as no interactions have been clinically observed. However, as both the medicines have the tendency to cause sleepiness, so caution may be needed in case both the medicines are used together as it may affect your ability to drive or work on a machine. Please consult your doctor before taking them together.

Q. Can I take Pregabalin with amitriptyline?
Pregabalin is known to increase the depressant action of amitriptyline. Taking the two medicines together can make you feel more sleepy, so, you should be careful while driving or if you are working with a machine. Consult your doctor before taking the medications together.

Q. Can I take Pregabalin with ibuprofen?
Pregabalin is not known to have any interaction with ibuprofen and they can be taken together. However, consult your doctor before taking these medications together.

Q. Can I take Pregabalin with diazepam?
Pregabalin may enhance the depressant effects of diazepam when used together. Taking them together can make you feel more sleepy, so, you should be careful while driving or if you are working with a machine. Consult your doctor before taking these medicines together.

Q. Can I take Pregabalin with paracetamol?
Pregabalin is not known to have any clinically meaningful interaction with paracetamol. They can be safely taken together. However, consult your doctor before taking these drugs together as interactions may occur.

Q. Does Pregabalin cause swelling?
Pregabalin is known to produce edema (swelling) by fluid (water) retention. Kindly consult your doctor if you develop swelling while taking Pregabalin.

Q. Does Pregabalin cause drowsiness (somnolence)?
One of the common side effects of Pregabalin use is drowsiness (somnolence). Consult your doctor if you experience any such symptom while taking Pregabalin especially if you are taking any other medicine which can make you sleepy.

Q. Does Pregabalin cause weight gain?
Weight gain can occur as a common side effect with Pregabalin use. It can be a result of increased appetite (feeling hungry) and fluid (water) retention. Consult your doctor if there is any change in your weight during therapy.

Q. Does Pregabalin cause hair loss?
Clinical studies have shown that Pregabalin can cause hair loss (alopecia) in some patients. It has also been associated with hirsutism (excessive hair growth). Consult your doctor if you notice any difference in your hair growth while taking Pregabalin.

Q. Does Pregabalin make you tired?
Pregabalin is known to cause tiredness (fatigue). Consult your doctor if you experience excessive tiredness while taking Pregabalin.

Q. Does Pregabalin cause water retention?
Pregabalin has been associated with fluid (water) retention and edema (swelling). Consult your doctor if you notice swelling of your body while taking Pregabalin therapy.

Q. Does Pregabalin make you hungry?
Pregabalin is known to increase appetite (make you feel hungry). Consult your doctor if there is a significant change in your appetite while taking Pregabalin.

Q. Does Pregabalin cause diarrhea?
Pregabalin use can cause diarrhea as a side effect. Consult your doctor if you have diarrhea while taking Pregabalin.

Q. Does Pregabalin help with sleep?
Pregabalin is not indicated for the treatment of any sleep problems. Rather, Pregabalin can cause somnolence (increased desire to sleep). Consult your doctor for the treatment of any sleep related problems.

• You may have to wait for 2 to 4 weeks to get the full effect.If your doctor asks you to stop Duloxetine, you should not discontinue it abruptly. Many patients tolerate decreasing 50% dose every 3 days however if the withdrawal symptoms emerge during tapering it would require more gradual tapering over few weeks.Inform your doctor if you have ever been diagnosed with any heart problems (heart attack, heart failure, slow or irregular heart rate).Inform your doctor if you have ever been diagnosed with kidney or liver problems.It can cause a sensation of restlessness or an inability to sit or stand still. This is most likely to occur within the first few weeks of treatment. You should tell your doctor if this happens to you.It may be more effective in some patients with depression who fails to respond to selective serotonin receptor inhibitors (SSRI) e.g. Fluoxetine.Monitor blood pressure (BP) frequently.
• You have been prescribed Pregabalin for treating and preventing nerve pain caused by diabetes and shingles.It may also be used for the treatment and prevention of seizures.Its side effects are usually mild and go away by themselves. It may cause sleepiness. Don't drive or do anything requiring concentration until you know how it affects you.Avoid consuming alcohol when taking Pregabalin, as it may cause excessive sleepiness or drowsiness.Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency.