Donepezil is generally used in treatment of Alzheimer's disease and dementia in Parkinson's disease It should be used in patients with moderate to severe Alzheimer's disease. Memantine is generally used in treatment of the treatment of Alzheimer's disease. It should be used in patients with moderate to severe Alzheimer's disease.
Insomnia (difficulty in sleeping)
Loss of appetite
How to use
Consume this medicine in the dosage and duration as per your doctors advise. While taking Donepezil, swallow it completely without crushing, breaking or chewing it. Donepezil is advised to be taken at a fixed time, but may be taken together with food (or) without food. Consume this medicine in the dosage and duration as per your doctors advise. While taking Memantine, swallow it completely without crushing, breaking or chewing it. Memantine is advised to be taken at a fixed time, but may be taken together with food (or) without food.
How it works
Memory loss in Alzheimer’s disease occurs due to disturbances of signal transmission in the brain. Donepezil is a cholinesterase inhibitor. It makes the condition better by increasing the levels of a chemical messenger (acetylcholine) involved in transmmissi. This improves memory and thinking. Memory loss in Alzheimer’s disease is due to an imbalance of chemical messengers in the brain. Memantine works by blocking the action of glutamate, a chemical messenger involved in the transmission of nerve signals.
Frequently Asked Questions
Q. What is Donepezil hydrochloride/ what is Donepezil hydrochloride used for/ what does Donepezil hydrochloride do? Donepezil hydrochloride belongs to a group of medicines called acetylcholinesterase inhibitors and is used to treat the symptoms of dementia (which includes increasing memory loss, confusion and behavioral changes) in people diagnosed as having mild and moderately severe Alzheimer's disease
Q. Does Donepezil Hcl work? Donepezil hydrochloride does work, but its effectiveness can be different based on individual response.
Q. Is Memantine a psychotropic drug? A psychotropic drug is a medicine affecting the mind, emotions, and behaviour. Memantine has a beneficial effect on the behavioural symptoms of patients with moderate to severe Alzheimer's Disease. Therefore it is considered as a psychotropic agent.
Q. Is Memantine a narcotic? No. Memantine is not a narcotic. It does not have habit forming potential.
Q. Is Memantine a mood stabiliser? No. Mood stabilisers are used to treat mania and bipolar disorder. Memantine is not approved for these conditions yet, although studies are going on for the role of Memantine in these diseases also.
Q. Is Memantine a nootropic. No. Memantine does not fit in the generally accepted "Nootropic" descriptor for healthy people. Nootropics are drugs which increase cognition/ motivation/ creativity in healthy individuals. Memantine, on the other hand, improves cognition in patients with Alzheimer's Disease.
Q. Is Memantine a cholinesterase inhibitor? No. Memantine does not function by inhibiting the cholinesterase enzyme found in the endings of nerve cells. Rather, it acts by preventing the toxicity of an excitatory substance called glutamate in the brain.
Q. Is Memantine a NMDA receptor antagonist? Yes. Memantine acts as an antagonist at the NMDA receptor. This is the receptor in the brain through which glutamate, an excitatory substance, damages the nerve cells in the brain, which is found in Alzheimer's disease.
Q. What is Cmax of Memantine? Cmax (Peak plasm concentration) of Memantine is 35-40 ng/ml.
Q. Can I take Memantine with vitamin D? It has been reported in some studies that a combination of Memantine and Vitamin D improves cognition in Alzheimer's Disease. However, more studies are required to confirm this finding.
Q. Can I take Memantine with vitamin E? Some studies have reported that among patients with mild to moderate Alzheimer's disease, taking alpha-tocopherol (Vitamin E) with Memantine slows the progressive functional decline. However, more studies are required to confirm this finding.
Q. When to start Memantine? Memantine is started when a person starts suffering from moderate to severe Alzheimer's Disease and has failed other options. Despite years of research for mild Alzheimer's Disease, Memantine has not been found to be useful in it.
Q. Why is Memantine prescribed? Memantine is prescribed to improve the cognitive (memory) function in patients with Alzheimer's Disease when other treatment options like cholinesterase enzyme inhibitors have failed.
Q. What is the interaction of Memantine with metformin? The interaction between Memantine and Metformin is minor. Memantine oral increases the level or effect of metformin by nonacidic drugs competing for the same pathway through the kidney.
Q. What is the interaction of Memantine with warfarin? No known interaction between Memantine and Warfarin has been found.
Q. Can Memantine used in dementia with Lewy bodies? The role of Memantine in Lewy Body Dementia (LBD) is controversial. Some studies suggest that it is safe and efficacious in this disease whereas others have shown exacerbation of LBD due to Memantine. Memantine is not approved for use in Lewy Body Dementia.
Q. Can Memantine combined with donepezil? A combination of Memantine and Donepezil can be given in moderate to severe Alzheimer's Disease. It has been shown that the combination may have additive effects i.e. effects of both drugs are added when given together in some studies.
Q. Can Memantine be used with rivastigmine? Memantine in combination with rivastigmine is safe and beneficial in patients with Alzheimer's Disease. Patients have improvement or stabilisation on dual therapy.
Q. Can Memantine be used for chronic pain? Memantine is not indicated for use in chronic pain. It has been proposed as a medication for the treatment of neuropathic pain for its mechanism, safety, lack of serious adverse effects, and the relatively rapid onset of action. However, studies have not been promising so far and its routine use in neuropathic pain is not currently recommended.
Q. Can Memantine be used for opiate withdrawal? Memantine is not indicated for use in Opioid withdrawal. In a number of small studies, it has been seen that Memantine decreased the expression of opioid physical dependence in humans but there is a need for more studies in this field.
Q. Can Memantine be used for autism? Memantine has failed to demonstrate clinical efficacy in autism. Studies are currently in progress for other clinical applications.
Q. Can Memantine use for dementia? Memantine has failed to demonstrate clinical efficacy in vascular dementia although it was well-tolerated.
You have been prescribed Donepezil to slow the progression of alzheimer's disease and treat dementia in parkinson's disease.It does not cure alzheimer's, but may help with brain function and doing daily activities.Take it with food to avoid an upset stomach.It may cause diarrhea, nausea, and vomiting. Drink plenty of fluids to keep yourself hydrated while taking Donepezil.Monitor your body weight regularly as both Donepezil and alzheimer's disease can cause weight loss.Don't drive or do anything that requires mental focus until you know how Donepezil affects you.Inform your doctor if you develop muscle tremors, especially if you have parkinson’s disease.
You have been prescribed Memantine to slow the progression of alzheimer's disease.Memantine is well tolerated and has lesser side-effects as compared to other similar medicines.Use caution while driving or doing anything that requires concentration until you know how Memantine affects you.Inform your doctor if you have a history of seizures, kidney disease, heart disease, or liver disease.Inform your doctor if you are pregnant, planning to conceive, or breastfeeding.
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