Rifampicin is generally used in treatment of leprosy and tuberculosis Isoniazid is generally used in treatment of the treatment of tuberculosis. It is typically also used treat inactive (latent) TB . Pyrazinamide is generally used in treatment of the treatment of tuberculosis.
Altered liver function test
Hepatitis (viral infection of liver)
Increased liver enzymes
Low blood platelets
Peripheral neuropathy (tingling and numbness of feet and hand)
How to use
Consume this medicine in the dosage and duration as per your doctors advise. While taking Rifampicin, swallow it completely without crushing, breaking or chewing it. Rifampicin is to be taken empty stomach. Consume this medicine in the dosage and duration as per your doctors advise. Dissolve it in a glass of water before taking it. Isoniazid is to be taken empty stomach.Avoid Isoniazid with tyramine-rich food such as cheese, smoked fish, meats and some types of beer. Consume this medicine in the dosage and duration as per your doctors advise. While taking Pyrazinamide, swallow it completely without crushing, breaking or chewing it. Pyrazinamide is to be taken with food.
How it works
Rifampicin is an antibiotic. It makes the condition better by deactivating RNA-polymerase(a bacterial enzyme) that's necessary for the bacteria to reproduce and carry out vital-functions. Isoniazid is an antibiotic. It kills the tuberculosis causing bacteria to make the condition better. Pyrazinamide is an antibiotic. It slows the growth of tuberculosis causing bacteria and works to make the condition better.
Frequently Asked Questions
Q. Is rifampin a penicillin/amoxicillin/sulfa drug? No. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It has a structure and mechanism of action different from penicillin or amoxicillin (amoxicillin belongs to the class of penicillin antibiotics). The chemical structure and mechanism of action of rifampin is different from sulfa drugs
Q. Is rifampin bacteriostatic or bactericidal? Rifampin is a bactericidal drug. It acts by blocking the activity of a bacterial enzyme called DNA-dependent RNA polymerase which essential for important life processes in the bacteria, thereby killing the bacteria
Q. Is rifampin an inducer or inhibitor? Rifampicin is an inducer of an important liver enzyme system that is responsible for the final processing and removal of several medicines from the body
Q. What is R-cin 600 used for? Rifampicin 600 is a trade name for active medicine rifampicin 600 mg.
Rifampicin is an antibiotic generally used in the treatment of tuberculosis and leprosy. it is also used in combination with other medicines to treat Legionnaires disease or serious staphylococcal infections infections-Brucellosis, and also be used in the prevention of meningococcal meningitis and Haemophilus influenza infections.
Q. What is R-cinex/Macox plus/R-cinex 600? R-cinex and Macox plus are trade names for a combination of active drugs rifampin and isoniazid. It is used in the treatment of tuberculosis. R-cinex 600 and Macox plus contains 600 mg of active drug rifampin and 300 mg of active drug isoniazid
Q. Can I take rifampin with ibuprofen/acetaminophen (Tylenol)? Rifampicin has not known to serious drug interaction with ibuprofen or acetaminophen. Consult our doctor about the medication you are currently using to avoid interactions that may decrease the effectiveness of any treatment or aggravate side effects
Q. Does rifampin cause weight gain/weight loss/ hair loss/ constipation/ yeast infection? No, Rifampicin is an antibiotic generally used in the treatment of tuberculosis and leprosy. weight gain, hair loss or constipation are not among the known side effects of Rifampicin and no known the effect of causing yeast infections.
Q. Does rifampin cause headaches? Yes, Rifampicin may cause a headache.
Q. Does rifampin change urine color/turn urine orange? Yes, Using Rifampicin may change the color of your urine to orange or brownish-red. But This effect is not harmful.
Q. Does rifampin cause liver damage?
Regular monitoring of liver function is essential while on treatment with Rifampicin. Using Rifampicinwith drugs like saquinavir, ritonavir can cause severe liver damage. Before taking Rifampicin you should consult your doctor if you have any liver problem. However, Rifampicin is safe when used at prescribed doses for the prescribed duration.
Q. Is Isoniazid an antibiotic? Yes, Isoniazid is an antibiotic. It is used in the prevention and treatment of tuberculosis or TB (a serious infection caused by bacteria that affects the lungs and in certain cases other parts of the body)
Q. Is Isoniazid chemotherapy/chemotherapy drug? Isoniazid is used in the treatment of tuberculosis. It act as a primary antibiotic .Do not confuse it with chemo medicines or chemotherapy used for the treatment of cancer
Q. Is Isoniazid bacteriostatic or bactericidal? Isoniazid stops or suppresses the growth of tuberculosis-causing bacteria by interfering with the formation of a protective outer covering which is required for their growth.so it is a bacteriostatic antibiotic.
Q. Is Isoniazid safe? Yes,Isoniazid is safe if used for prescribed duration in prescribed doses as recommended by your doctor.
Q. Is Isoniazid a MAOI? Isoniazid it is not used as a monoamine oxidase inhibitor (MAOI). It has very weak inhibitory activity on enzymes monoamine oxidases (MAO)
Q. Is Isoniazid a sulfa drug? The chemical structure and mechanism of action of Isoniazid is different from sulfa drugs.
Q. Is Isoniazid an inducer or inhibitor? Isoniazid is an inhibitor (decreases activity). It inhibits an important liver enzyme system that is responsible for the final processing and elimination of several drugs from the body.
Q. Can I take Isoniazid with ibuprofen/Benadryl/Nyquil/Aleve/Mucinex/amoxicillin? There no known serious drug interactions of Isoniazid with ibuprofen, paracetamol (trade name: Tylenol), naproxen (trade name: Aleve), amoxicillin or any active drug present in Nyquil or Mucinex. Please inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects
Q. Does Isoniazid cause weight loss/weight gain/hair loss/diarrhea/affect menstruation? Changes in weight (gain/loss), hair loss, diarrhea or changes in menstruation don't seem to be among the known side effects of Isoniazid . you will experience few of those side effects while on multi drug (including ) treatment for T.B
Q. Does Isoniazid cause acne/make you tired/cause constipation? While on treatment with Isoniazid you may experience unusual tiredness, constipation or acne. Always inform your physician about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects.
Q. Does Isoniazid affect birth control? Isoniazid has no known interaction with normally used oral contraceptives (birth management pills). However, multidrug treatment for T.B. contains active drug rifampin that decreases the effectiveness of oral contraceptives and hampers contraception.
Q. What is Pyrazinamide and what is it used for? Pyrazinamide is an antibiotic. It is used in combination with other antibiotics in the treatment of tuberculosis
Q. Is Pyrazinamide bactericidal? Pyrazinamide belongs to both bacteriostatic and a bactericidal antibiotic.In certain cases it stops the growth of bacteria (bacteriostatic) and in other cases it kills the bacteria (bactericidal) that causes tuberculosis.
Q. How does Pyrazinamide work/treat tuberculosis? Though the exact mechanism of Pyrazinamide is unknown, it kills or halts the growth of bacteria that generates tuberculosis (Mycobacterium tuberculosis).
Q. How does Pyrazinamide cause hyperuricemia and gout? Pyrazinamide in the body gets transformed to pyrazinoic acid that blocks the discharge of urates via kidneys. As a result excess uric acid will be present in the joints causing pain, swelling, redness and stiffness in joints (gout).
Your doctor has prescribed Rifampicin to cure your infection and improve symptoms.It is best taken on an empty stomach. If you get an upset stomach, try taking it with small portions of food.Â Your urine, tears and other secretions may become orange-red in colour. Avoid using contact lenses since they may become discolored.Tell your doctor about all other medicines you are taking as Rifampicin can interact with many medicines.Avoid taking hormone-based birth control methods as Rifampicin may decrease their effectiveness.Tell your doctor immediately if you experience unusual tiredness or loss of appetite, fever or chills.
Your doctor has prescribed Isoniazid to cure your infection and improve symptoms.It is best taken on an empty stomach.You must also take a vitamin B6 supplement while on Isoniazid.Tell your doctor immediately if you experience vision changes, loss of appetite, tiredness, stomach pain, nausea or vomiting, yellow skin or eyes or dark-colored urine.
Your doctor has prescribed Pyrazinamide to cure your infection and improve symptoms.You can take it with food or on an empty stomach.Pyrazinamide may cause a rash after sun exposure; hence avoid sun exposure.Tell your doctor immediately if you experience skin rash, severe itching or hives, pain or swelling in the joints, yellowing of the skin or eyes or dark urine, weakness, nausea or vomiting, loss of appetite.
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